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Full list of Publications:

Selected Publications

  1. Chan W*, Ham Y-H, Jin L, Chan H-W, Wong Y-L, Chan C-K, Chung P-Y, (2019) Quantification of a novel DNA-protein crosslink product formed by reacting apurinic/apyrimidinic sites in DNA with cysteine residues in protein by liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method. Anal Chem, 91:4987-4994.
  2. Chan C-K,  Liu Y, Nikola M. Pavlović,* Chan W*, (2019) Aristolochic Acids: Newly Identified Exposure Pathways of this Class of Environmental and Food-Borne Contaminants and its Potential Link to Chronic Kidney Diseases. Toxics, 7, 14; doi:10.3390/toxics7010014
  3. Chan C-K, Nikola M. Pavlović,* Chan W*, (2019) Development of a novel liquid chromatography-tandem mass spectrometric method for aristolochic acids detection: Application in food and agricultural soil analyses. Food Chemistry, 289:673-679.
  4. Chan W*, Zhao Y, Zhang J, (2019) Evaluating the performance of sample preparation methods for ultra-performance liquid chromatography/mass spectrometry based serum metabonomics. Rapid Commun Mass Spectrom. 33: 561-568.
  5. Liu Y, Chan C-K, Jin L, Wong S-K, Chan W*, (2019) Quantitation of DNA Adducts in Target and Non-Target Organs of Aristolochic Acid I-Exposed Rats by LC-MS/MS Coupled with Stable Isotope-Dilution Method: Correlating DNA Adduct Levels with Organotropic Activities. Chem. Res. Toxicol. 32: 397−399.
  6. Chan W*, (2019) Investigation of the chemical structure and formation mechanism of polydopamine from self-assembly of dopamine by liquid chromatography/mass spectrometry coupled with isotope-labelling techniques. Rapid Commun Mass Spectrom. 33: 429-436.
  7. Chan C-K, Liu Y, Nikola Pavlović, Chan W*, (2018) The Etiology of Balkan Endemic Nephropathy: An Update on Aristolochic Acids Exposure Mechanisms. Chem. Res. Toxicol., 31: 1109-1110 (ToxWatch) .
  8. Li W, Chan C-K, Liu Y, Yao J, Branka Mitić, Emina N. Kostic, Biljana S. Milosavljevic, Ivana Davinić, William H Orem, Calin A. Tatu, Peter C. Dedon, Nikola M. Pavlović, and Chan W*, (2018) Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake. J Agric Food Chem., 66: 11468-11476.
  9. Chan W*, Wong S-K, and Li W, (2018) Quantification of DNA and Protein Adducts of 1-Nitropyrene: Significantly Higher Levels of Protein than DNA Adducts in the Internal Organs of 1-Nitropyrene Exposed Rats. Chem. Res. Toxicol., 31: 680-687.
  10. Li W, Chan C-K, Wong Y-L, Chan K-K, Chan H-W, and Chan W*, (2018) Cooking methods employing natural anti-oxidant food additives effectively reduced concentration of nephrotoxic and carcinogenic aristolochic acids in contaminated food grains. Food Chem., 264: 270-276.
  11. Wang Y, Chan K-K, and Chan W*, (2017) Plant uptake and metabolism of nitrofuran antibiotics in spring onion grown in nitrofuran contaminated soil. J Agric Food Chem., 65: 4255-4261.
  12. Deng K and Chan W*, (2017) Development of a QuEChERS-based method for determination of carcinogenic 2-nitrofluorene and 1-nitropyrene in rice grains and vegetables: A comparative study with Benzo[a]pyrene. J Agric Food Chem., 65: 1992-1999.
  13. Meng X and Chan W*, (2017) Determination of 2-alkylcyclobutanones in ultraviolet light-irradiated fatty acids, triglycerides, corn oil, and pork samples: Identifying a new source of 2-alkylcyclobutanones. Food Chem., 217: 352-359.
  14. Chan W*, Pavlović NM*, Li W, Chan C-K, Liu J, Deng K, Wang Y, Milosavljević B, and Kostić EN, (2016) Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy.J Agric Food Chem., 64:5928−5934. **Research Article of the Year Award**
  15. Wang Y, Wong T-Y, and Chan W*, (2016) Quantitation of the DNA adduct of semicarbazide in organs of semicarbazide-treated rats by isotope-dilution liquid chromatography-tandem mass spectrometry: a comparative study with the RNA adduct. Chem. Res. Toxicol., 29: 1560-1564.
  16. Liu J, Chan K-K, and Chan W*, (2016) Identification of protein thiazolidination as a novel molecular signature for oxidative stress and formaldehyde exposure. Chem. Res. Toxicol., 29: 1865-1871.
  17. Hu Q, Meng X, Chan W*, (2016) An Investigation on the Chemical Structure of Nitrogen and Sulfur-codoped Carbon Nanoparticles by Ultra-performance Liquid Chromatography-tandem Mass Spectrometry. Anal. Bioanal. Chem., 408: 5347-5357.
  18. Wang Y, Chan HW, Chan W*, (2016) Facile Formation of DNA Adduct of Semicarbazide in Reaction with Apurinic/Apyrimidinic Sites in DNA. Chem Res Toxicol., 29: 834-840.
  19. Wang Y, Chan W*, (2016) Automated In-Injector Derivatization Combined with High Performance Liquid Chromatography-Fluorescence Detection for the Determination of Semicarbazide in Fish and Bread Samples, J Agric Food Chem., 64: 2802−2808.
  20. Meng X, Tong T, Wang L, Liu H, and Chan W*, (2016) Determination of 2-Alkylcyclobutanones by Combining Precolumn Derivatization with 1-Naphthalenyl Hydrazine and Ultra-Performance Liquid Chromatography with Fluorescence Detection, Anal. Bioanal. Chem., 408: 3707-3714.
  21. Hu Q, Meng X, Choi MM, Gong X, and Chan W*, (2016) Separation and structural elucidation of carbon nanoparticles by ultra-performance liquid chromatography coupled with electrospray ionisation quadrupole time-of-flight tandem mass spectrometry, Anal. Chim. Acta., 911: 100-107.
  22. Liu J, Meng X, and Chan W*, (2016) Quantitation of Thioprolines in Grape Wine by Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry, J. Agric. Food Chem., 64:1361-1366.
  23. Li W, Hu Q, and Chan W*, (2016) Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water, J. Agric. Food Chem., 64:107-112.
  24. Leung EM, Deng K, Wong T-Y, and Chan W*, (2015) Determination of DNA adducts by combining acid-catalyzed hydrolysis and chromatographic analysis of the carcinogens-modified nucleobases, Anal Bioanal Chem, 408:953-961.
  25. Li W, Hu Q, and Chan W*, (2015) Mass spectrometric and spectrofluorometric studies of the interaction of aristolochic acids with proteins, Sci. Rep. 5:15192 | DOI: 10.1038/srep15192.
  26. Jumpathong W, Chan W, Taghizadeh K, Ramesh BI, and Dedon PC*, (2015) Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation, Proc. Natl. Acad. Sci. USA, E4845–E4853.
  27. Li Y, Liu J, Wang Y, Chan H-W, Wang L*, and Chan W*, (2015) Mass spectrometric and spectrophotometric analyses reveal an alternative structure and a new formation mechanism for melanin, Anal. Chem., 7:7958−7963.
  28. Leung EM and Chan W*, (2015) Quantification of aristolochic acid-RNA adducts in the urine of aristolochic acid-treated rats by liquid chromatography tandem mass spectrometry, Chem Res Toxicol. 28: 567-569.
  29. Deng K, Wong T-Y, Wang Y, Leung EM, and Chan W*, (2015) Combination of pre-column nitro-reduction and ultra-performance liquid chromatography with fluorescence detection for the sensitive quantification of 1-nitronaphthalene, 2-nitrofluorene, and 1-nitropyrene in meat products, J. Agric. Food Chem. 63: 3161-3167.
  30. Leung EM and Chan W*, (2015) Comparison of DNA and RNA adduct formation: Significantly higher levels of RNA than DNA modifications in the internal organs of aristolochic acids-dosed rats, Chem Res Toxicol., 28: 248–255.
  31. Liu J and Chan W*, (2015) Quantification of thiazolidine-4-carboxylic acid in toxicant-exposed cells by isotope-dilution liquid chromatography–mass spectrometry reveals intrinsic antagonistic response to oxidative stress-induced toxicity, Chem Res Toxicol., 28: 394–400.
  32. Wang Y and Chan W*, (2014) Determination of aristolochic acids by high-performance liquid chromatography with fluorescence detection, J. Agric. Food Chem., 62: 5859-5864.
  33. Leung EM and Chan W*, (2014) Noninvasive measurement of aristolochic acid-DNA adducts in urine samples from aristolochic acid-treated rats by liquid chromatography coupled tandem mass spectrometry: Evidence for DNA repair by nucleotide-excision repair mechanisms, Mutat. Res., 766-767: 1-6.
  34. Chan W*, Ye Y, and Leung EM, (2014) Rapid identification of γ-irradiated food by direct solvent extraction and liquid chromatography-tandem mass spectrometric analysis of 2-dodecylcyclobutanone: Application in surveillance of irradiated food, Food Chem, 161: 312-316.
  35. Leung EM and Chan W*, (2014) A novel reversed-phase HPLC method for the determination of urinary creatinine by pre-column derivatization with ethyl chloroformate: Comparative studies with the standard Jaffé and isotope-dilution mass spectrometric assays, Anal Bioanal Chem, 406: 1807-1812.
  36. Leung EM, Tang PN, Ye Y, and Chan W*, (2013) Analysis of 2-alkylcyclobutanones in cashew net, nutmeg, apricot kernel, and nutmeg samples: Re-evaluating the uniqueness of 2-alkylcyclobutanones for irradiated food identification, J. Agric. Food Chem. 61: 9950-9954.
  37. Ye Y, Liu H, Horvatovich P, and Chan W*, (2013) Liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 2-alkylcyclobutanones in irradiated chicken by pre-column derivatization with hydroxylamine, J. Agric. Food Chem, 61: 5758-5763.
  38. Hu Q, Paau MC, Zhang Y, Chan W*, Gong XJ, Zhang L, and Choi MM*, (2013) Capillary electrophoretic separation of water-soluble carbon nanodots synthesized by microwave-assisted pyrolysis, J. Chromatog. A 1304: 234-240.
  39. Zhang Y, Hu Q, Paau MC, Xie S, Gao P, Chan W*, and Choi MM*, (2013) Probing histidine-stabilized gold nanoclusters product by high-performance liquid chromatography and mass spectrometry, J. Phys. Chem. C 117: 18697-18708.
  40. Li J, Leung EM, Choi MM, and Chan W*, (2013) Combination of pentafluorophenylhydrazine derivatization and isotope dilution LC-MS/MS techniques for the quantification of apurinic/apyrimidinic sites in cellular DNA, Anal Bioanal Chem, 405: 4059-4066.
  41. Li J and Chan W*, (2013) Investigation of the biotransformation of osthole by LC-MS/MS, J. Pharmaceut. Biomed. Anal. 74: 156-161.
  42. Chan W, Chen BZ, Wang LR, Taghizadeh K, Demott MS, Razskazovskiy Y, and Dedon PC*, (2010) Quantification of the 2-deoxyribonolactone and nucleoside 5’-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: Differential effects of γ-radiation and Fe2+-EDTA, J. Am. Chem. Soc. 132: 6145-6153.
  43. Chan W, Yue H, Poon WY, Chan Y-W, Schmitz Oliver J, Kwong, DWJ, Wong RNS, Cai ZW*, (2008) Quantification of aristolochic acid-derived DNA adducts in rat kidney and liver by using liquid chromatography-electrospray Ionization mass spectrometry, Mutat. Res. 646: 17-24.
  44. Chan W, Luo HB, Zheng YF, Cheng YK, and Cai ZW*, (2007) Investigation of the metabolism and reductive activation of carcinogenic aristolochic acids in rats, Drug Metab. Dispos. 35: 866-874.
  45. Chan W, Lee KC, Liu N, and Cai ZW*, (2007) A sensitive enhanced high performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines, J. Chromatog. A 1164: 113-119.
  46. Chan W, Zheng YF, and Cai ZW*, (2007) Liquid chromatography-tandem mass spectrometry analysis of the DNA adducts of aristolochic acids, J. Am. Soc. Mass Spectrom. 18: 642-650.
  47. Chan W, Hui KM, Poon WT, Lee KC, and Cai ZW*, (2006) Differentiation of herbs linked to “Chinese herb nephropathy” from the liquid chromatographic determination of aristolochic acids, Anal. Chem. Acta 579:112-116.

 

Full list of Publications: